Josep Dalmau Selected Research

Memory Disorders (Memory Loss)

1/2022	Human CASPR2 Antibodies Reversibly Alter Memory and the CASPR2 Protein Complex.
1/2022	Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice.
1/2022	Human Metabotropic Glutamate Receptor 5 Antibodies Alter Receptor Levels and Behavior in Mice.
11/2021	Blocking Placental Class G Immunoglobulin Transfer Prevents NMDA Receptor Antibody Effects in Newborn Mice.
1/2020	Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis.
1/2020	NMDAR Antibodies Alter Dopamine Receptors and Cause Psychotic Behavior in Mice.
11/2018	LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory.
10/2017	Antibody-associated CNS syndromes without signs of inflammation in the elderly.
1/2016	Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity.
3/2015	Cellular plasticity induced by anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis antibodies.

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Josep Dalmau Research Topics

Disease

104	Encephalitis (Encephalitis, Rasmussen) 03/2024 - 02/2004
53	Neoplasms (Cancer) 01/2022 - 04/2000
40	Anti-N-Methyl-D-Aspartate Receptor Encephalitis 10/2023 - 12/2008
36	Autoimmune Diseases of the Nervous System 01/2024 - 01/2010
23	Seizures (Absence Seizure) 03/2024 - 08/2005
22	Limbic Encephalitis (Paraneoplastic Limbic Encephalitis) 01/2023 - 08/2005
12	Nervous System Diseases (Neurological Disorders) 01/2024 - 04/2008
12	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2023 - 03/2003
11	Psychotic Disorders (Schizoaffective Disorder) 10/2023 - 07/2012
11	Memory Disorders (Memory Loss) 01/2022 - 07/2010
10	Glioma (Gliomas) 03/2024 - 08/2010
10	Opsoclonus-Myoclonus Syndrome (Kinsbourne Syndrome) 01/2021 - 03/2003
10	Teratoma (Teratoid Tumor) 01/2020 - 08/2005
10	Cerebellar Ataxia (Dysmetria) 01/2020 - 04/2010
10	Paraneoplastic Cerebellar Degeneration 08/2014 - 01/2003
9	Thymoma (Thymic Carcinoma) 01/2021 - 08/2005
8	Ataxia (Dyssynergia) 01/2023 - 02/2004
8	Neurologic Manifestations (Neurological Manifestations) 12/2020 - 01/2003
8	Herpes Simplex Encephalitis (Herpes Encephalitis) 11/2019 - 12/2012
7	Brain Diseases (Brain Disorder) 12/2023 - 07/2010
7	Optic Neuritis (Retrobulbar Neuritis) 01/2023 - 02/2004
7	Neuromyelitis Optica (Devic's Disease) 01/2023 - 12/2007
7	Epilepsy (Aura) 01/2020 - 04/2009
7	Hodgkin Disease (Hodgkin's Disease) 08/2014 - 01/2003
6	Mental Disorders (Mental Disorder) 03/2024 - 05/2016
6	Movement Disorders (Movement Disorder) 01/2023 - 01/2011
6	Sleep Wake Disorders 01/2023 - 09/2014
6	Myoclonus (Nocturnal Myoclonus) 01/2023 - 01/2013
6	Leukocytosis (Pleocytosis) 01/2022 - 08/2005
6	Status Epilepticus (Complex Partial Status Epilepticus) 01/2022 - 10/2013
6	Stiff-Person Syndrome (Stiff Man Syndrome) 01/2020 - 04/2010
6	Ovarian Teratoma 01/2020 - 01/2007
6	Dyskinesias (Dyskinesia) 11/2019 - 10/2010
6	Isaacs Syndrome (Neuromyotonia) 01/2018 - 08/2010
5	Cognitive Dysfunction 10/2023 - 10/2014
5	Tremor (Tremors) 01/2023 - 07/2011
5	Multiple Sclerosis 01/2023 - 03/2012
5	Schizophrenia (Dementia Praecox) 10/2022 - 10/2012
5	Tauopathies 11/2019 - 06/2014
5	Hypoventilation 01/2019 - 12/2007
5	Lung Neoplasms (Lung Cancer) 04/2016 - 09/2007
5	Paraneoplastic Syndromes (Paraneoplastic Syndrome) 09/2012 - 02/2004
4	Nervous System Paraneoplastic Syndromes 01/2024 - 01/2003
4	Demyelinating Diseases (Demyelinating Disease) 11/2021 - 03/2014
4	Disease Progression 01/2021 - 10/2014
4	Cerebellar Diseases (Cerebellar Syndrome) 12/2020 - 01/2003
4	Chorea (Rheumatic Chorea) 10/2017 - 08/2011
4	Parasomnias (Parasomnia) 05/2017 - 06/2014
4	Myasthenia Gravis 03/2017 - 07/2007
3	Progressive Encephalomyelitis with Rigidity 01/2021 - 01/2013
3	Autoimmune Diseases (Autoimmune Disease) 11/2019 - 10/2014
3	Autoimmune limbic encephalitis 11/2018 - 06/2014
3	Dementia (Dementias) 01/2018 - 10/2014
3	Diarrhea 04/2017 - 01/2013
3	Sepsis (Septicemia) 03/2017 - 05/2014
3	Viral Encephalitis 06/2014 - 02/2011
3	Ocular Motility Disorders (Convergence Insufficiency) 05/2014 - 02/2004
2	Infections 10/2023 - 01/2023

Drug/Important Bio-Agent (IBA)

162	AntibodiesIBA 01/2024 - 07/2002
80	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2023 - 01/2007
44	Proteins (Proteins, Gene)FDA Link 03/2024 - 01/2003
40	AutoantibodiesIBA 01/2024 - 11/2008
24	AntigensIBA 01/2023 - 07/2002
22	Immunoglobulin G (IgG)IBA 01/2023 - 03/2010
18	N-Methylaspartate (NMDA)IBA 01/2020 - 11/2008
14	AutoantigensIBA 05/2014 - 01/2003
10	Leucine (L-Leucine)FDA Link 03/2024 - 08/2010
10	Biomarkers (Surrogate Marker)IBA 01/2023 - 02/2004
10	Surface Antigens (Surface Antigen)IBA 01/2023 - 09/2012
8	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2020 - 01/2010
8	AMPA Receptors (AMPA Receptor)IBA 01/2019 - 04/2009
8	Intravenous Immunoglobulins (IVIG)FDA Link 01/2016 - 05/2007
7	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 11/2018 - 10/2005
6	Glycine Receptors (Glycine Receptor)IBA 01/2021 - 04/2010
6	SteroidsIBA 01/2020 - 01/2013
6	EpitopesIBA 04/2016 - 01/2003
5	AcidsIBA 01/2021 - 06/2012
5	Potassium Channels (Potassium Channel)IBA 04/2017 - 04/2010
5	GABA-B ReceptorsIBA 12/2012 - 01/2010
4	anti-leucine-rich glioma-inactivated 1 autoantibodyIBA 01/2023 - 08/2010
4	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2023 - 05/2007
4	Immunoglobulins (Immunoglobulin)IBA 11/2021 - 05/2014
4	adenylate kinase 5IBA 01/2019 - 05/2007
4	1,3-dipropyl-8-phenylxanthineIBA 10/2017 - 01/2013
4	Neurotransmitter Receptors (Neurotransmitter Receptor)IBA 01/2017 - 04/2009
4	Membrane Proteins (Integral Membrane Proteins)IBA 01/2017 - 12/2007
4	Aminobutyrates (Aminobutyric Acid)IBA 06/2014 - 06/2012
4	Glutamate Receptors (Glutamate Receptor)IBA 02/2011 - 11/2008
3	Myelin-Oligodendrocyte GlycoproteinIBA 01/2023 - 02/2015
3	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2021 - 04/2010
3	Immunoglobulin A (IgA)IBA 02/2019 - 10/2014
3	Immunoglobulin M (IgM)IBA 02/2019 - 10/2014
3	Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesIBA 04/2017 - 01/2013
3	Epidermal Growth Factor (EGF)IBA 08/2014 - 12/2012
3	amphiphysinIBA 10/2013 - 08/2011

Therapy/Procedure

38	Immunotherapy 03/2024 - 10/2005
22	Therapeutics 12/2023 - 01/2003
4	Drug Therapy (Chemotherapy) 08/2014 - 01/2007
3	Plasma Exchange 10/2013 - 05/2007
2	Aftercare (After-Treatment) 03/2024 - 01/2018